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KMID : 0616120090400010041
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 1 p.41 ~ p.45
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Neuroprotective Effects of Some Plant Extracts Against Dopamine-induced Oxidative Stress on Neuronal Cell
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Koo Uk
Lee Hak-Ju
Lee Dong-Ho
Lee Hyun-Jung
Ham Ah-Rom
Mar Woong-Chon
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Abstract
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Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzhemier’s disease. Neuropathologically, PD is characterized by the selective loss of dopaminergic neurons. The neuronal toxicity of cytosolic excess dopamine (DA) has been described in many studies using several cell lines. In dopaminergic neurons, cytosolic excess DA is easily oxidized via monoamine oxidase (MAO)-B, tyrosinase or by auto-oxidation to produce neurotoxic metabolites such as DA quinone. So, in the present study, we induced cell death by treatment of DA (600μM) in human neuroblastoma SH-SY5Y cell which was treated samples before 24 hr, and cell viability was measured by fluorescence activated cell sorter (FACs) analysis. Of those tested, the extracts of Poria cocos (赤茯笭)(whole), Gastrodia elata (rhizomes), Eucommia ulmoides (炒)(barks), Syneilesis palmata (whole), Acorus gramineus (rhizomes), Ligustrum japonicum (leaves) showed neuroprotective effects in dose dependent manner.
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KEYWORD
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Dopamine, Neuroprotective effects, FACs analysis, EC50
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